Low Dose Naltrexone
Immune balance. Natural resilience.
A compounded, ultra-low dose (1.5–4.5mg) of a long-trusted medication — reimagined for modern longevity. Instead of suppressing, it gently signals your body to produce more of its own endorphins, calming inflammation and restoring immune balance from within.
Physician reviewed
Personalized protocol
Free discreet shipping
Select your plan
Choose your Low Dose Naltrexone plan
Choose your supply
Visible results start around month 3. Lock in your supply upfront.
*Medications only issued when clinically appropriate after provider evaluation. Shape Meds does not manufacture compounded medications. Actual product appearance may differ from images.
The protocol
What is Low Dose Naltrexone?
A compounded, ultra-low dose (1.5–4.5mg) of naltrexone — a long-trusted medication reimagined for modern longevity. A brief, transient blockade of opioid receptors triggers a sustained endorphin rebound, calming inflammation and modulating immunity. Studied for autoimmune conditions, chronic pain, fibromyalgia and inflammatory bowel disease. Eligibility, dosing and ongoing monitoring are determined by a licensed provider through our telehealth platform.
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The mechanism
How it works
N°01
Endorphin rebound
LDN transiently blocks opioid receptors for a few hours. When the blockade wears off, the body overcompensates by producing more endorphins and enkephalins — natural mood-regulating and immune-supporting peptides.
N°02
Immune modulation
LDN modulates microglial activity in the brain and peripheral immune cells, reducing pro-inflammatory cytokines — beneficial for autoimmune conditions, chronic pain and neuroinflammation.
N°03
Glial cell regulation
By calming overactivated microglial cells, LDN may reduce neuroinflammation and support healthier brain function — with emerging evidence for benefits in fatigue, mood and cognitive clarity.
N°02 — Outcomes
The results
Transformative results
- 01Supports natural endorphin production and mood regulation
- 02Calms pro-inflammatory cytokines and microglial activity
- 03Studied for autoimmune conditions and chronic pain
- 04Supports deeper, more restorative sleep
- 05Gentle, well-tolerated, once-nightly dosing
Your protocol timeline
What you
can expect.
Phase 01
Weeks 1 → 4
Start low to assess tolerance. Vivid dreams and mild sleep changes are common early — they fade within two weeks.
Phase 02
Weeks 4 → 8
Inflammation markers begin to drop. Many women notice less pain, brighter mood and better stress tolerance as endorphin signaling rebounds.
Phase 03
Months 3 → 6
Full immune-modulating effect. Autoimmune flares, chronic pain and fatigue typically reach their new lower baseline.
✦ How it works
Get started in three simple steps
Your personalized treatment plan is just minutes away.
≈ 5 minutes
Share your story
A brief, 100% online health assessment from the comfort of your home.
Within 24 hours
A clinician reviews
Board-certified physicians review your answers and build a tailored plan within 24 hours.
Free shipping
Care, delivered
If a prescription is granted, it ships discreetly to your door — free.
FAQ
Questions,
answered.
Everything you need to know before starting your protocol. Still curious? Our care team is one message away.
01What can I expect with Low Dose Naltrexone treatment?
Most women start on a low dose to assess tolerance in the first month. Inflammation and pain markers begin improving between weeks four and eight, with full immune-modulating benefits typically reached by months three to six.
02What are the possible side effects of Low Dose Naltrexone?
The most common early effects are vivid dreams or mild sleep disruption, which typically fade within two weeks. Your clinician reviews your history and titrates your dose to minimize side effects.
03How is LDN taken?
One low-dose (1.5–4.5mg) tablet or capsule nightly. Your clinician sets your starting dose and titrates based on how you respond.
04Who is eligible?
Eligibility, dosing and ongoing monitoring are determined by a US-licensed provider through our telehealth intake. Individual response varies.
Membership
What's included
One price. Everything you need — prescription, physician care and concierge support.
Treatment + ongoing care
Your prescription plus continuous physician support.
Free delivery to your door
Discreet, fast shipping included with every order.
Online doctor consultation
Evaluated by a licensed U.S. physician — no office visit needed.
Message your provider anytime
Ongoing care and adjustments whenever you need them.
100% money-back guarantee
Full refund if you're not approved for treatment.