Low Dose Naltrexone
Metabolic support. Gentle regulation.
A compounded, ultra-low dose (1.5–4.5mg) of a long-trusted medication — used off-label to support appetite regulation, calm inflammation and restore metabolic balance from within.
Physician reviewed
Personalized protocol
Free discreet shipping
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Choose your Low Dose Naltrexone plan
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Visible results start around month 3. Lock in your supply upfront.
*Medications only issued when clinically appropriate after provider evaluation. Shape Meds does not manufacture compounded medications. Actual product appearance may differ from images.
The protocol
What is Low Dose Naltrexone?
A compounded, ultra-low dose (1.5–4.5mg) of naltrexone — a long-trusted medication reimagined for metabolic and longevity care. A brief, transient blockade of opioid receptors triggers a sustained endorphin rebound, calming inflammation and modulating immunity. Studied for appetite regulation, autoimmune conditions and chronic pain. Eligibility, dosing and ongoing monitoring are determined by a licensed provider through our telehealth platform.
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The mechanism
How it works
N°01
Endorphin rebound
LDN transiently blocks opioid receptors for a few hours. When the blockade wears off, the body overcompensates by producing more endorphins and enkephalins — natural mood-regulating and immune-supporting peptides.
N°02
Immune modulation
LDN modulates microglial activity in the brain and peripheral immune cells, reducing pro-inflammatory cytokines that interfere with metabolic health.
N°03
Appetite & reward signaling
By calming overactivated glial cells and rebalancing endorphin signaling, LDN may help regulate reward-driven eating and support steadier appetite control.
N°02 — Outcomes
The results
Transformative results
- 01Supports gentle appetite regulation and reward balance
- 02Calms pro-inflammatory cytokines and microglial activity
- 03Studied for autoimmune conditions and chronic pain
- 04Supports deeper, more restorative sleep
- 05Gentle, well-tolerated, once-nightly dosing
Your protocol timeline
What you
can expect.
Phase 01
Weeks 1 → 4
Start low to assess tolerance. Vivid dreams and mild sleep changes are common early — they fade within two weeks.
Phase 02
Weeks 4 → 8
Inflammation markers begin to drop. Many patients notice less pain, brighter mood, steadier appetite and better stress tolerance as endorphin signaling rebounds.
Phase 03
Months 3 → 6
Full immune-modulating effect. Inflammation, chronic pain and fatigue typically reach a new lower baseline.
✦ How it works
Get started in three simple steps
Your personalized treatment plan is just minutes away.
≈ 5 minutes
Share your story
A brief, 100% online health assessment from the comfort of your home.
Within 24 hours
A clinician reviews
Board-certified physicians review your answers and build a tailored plan within 24 hours.
Free shipping
Care, delivered
If a prescription is granted, it ships discreetly to your door — free.
FAQ
Questions,
answered.
Everything you need to know before starting your protocol. Still curious? Our care team is one message away.
01What can I expect with Low Dose Naltrexone treatment?
Most patients start on a low dose to assess tolerance in the first month. Inflammation and appetite regulation begin improving between weeks four and eight, with full benefits typically reached by months three to six.
02What are the possible side effects of Low Dose Naltrexone?
The most common early effects are vivid dreams or mild sleep disruption, which typically fade within two weeks. Your clinician reviews your history and titrates your dose to minimize side effects.
03How is LDN taken?
One low-dose (1.5–4.5mg) tablet or capsule nightly. Your clinician sets your starting dose and titrates based on how you respond.
04Who is eligible?
Eligibility, dosing and ongoing monitoring are determined by a US-licensed provider through our telehealth intake. Individual response varies.
Membership
What's included
One price. Everything you need — prescription, physician care and concierge support.
Treatment + ongoing care
Your prescription plus continuous physician support.
Free delivery to your door
Discreet, fast shipping included with every order.
Online doctor consultation
Evaluated by a licensed U.S. physician — no office visit needed.
Message your provider anytime
Ongoing care and adjustments whenever you need them.
100% money-back guarantee
Full refund if you're not approved for treatment.