Metformin XR
Live longer. Function better.
Clinician-prescribed metabolic support. Metformin improves insulin sensitivity, steadies blood sugar and activates the same cellular pathways studied in longevity medicine.
Physician reviewed
Personalized protocol
Free discreet shipping
Select your plan
Choose your Metformin plan
Choose your supply
Visible results start around month 3. Lock in your supply upfront.
*Medications only issued when clinically appropriate after provider evaluation. Shape Meds does not manufacture compounded medications. Actual product appearance may differ from images.
The protocol
What is Metformin.
Metformin is an oral medication FDA-approved for the management of type 2 diabetes. When prescribed off-label by a US-licensed clinician, it may be used to support insulin sensitivity and metabolic health. Off-label use is not FDA-approved for this purpose; risks, benefits and alternatives will be reviewed by your clinician. Individual results vary.
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The mechanism
How it works
N°01
AMPK activation
Metformin activates AMP-activated protein kinase (AMPK), a key energy sensor that promotes fat oxidation, glucose uptake and mitochondrial biogenesis — mimicking the effects of fasting.
N°02
Insulin sensitivity & glycemic control
It lowers circulating insulin and glucose levels, helping reduce systemic inflammation and oxidative stress, two hallmarks of aging and metabolic decline.
N°03
mTOR pathway modulation
Research suggests Metformin may modulate the mTOR pathway and support autophagy, a cellular cleanup and repair process being studied in longevity research.
N°02 — Outcomes
The results
Transformative results
- 01Enhances insulin sensitivity and stabilizes blood sugar
- 02May reduce visceral fat and improve body composition
- 03Supports mitochondrial function and metabolic flexibility
- 04May reduce the risk of age-related diseases (heart disease, cancer, cognitive decline)
- 05Activates cellular repair pathways (AMPK, autophagy)
Your protocol timeline
What you
can expect.
Phase 01
Weeks 1 → 2
Mild GI adjustment is common and resolves with food. Fasting glucose begins to drop within the first week.
Phase 02
Weeks 4 → 8
Insulin sensitivity improves. Cravings reduce, appetite stabilizes, and weight loss may begin — typically 2–5% of body weight by month two.
Phase 03
Months 3 → 6
HbA1c lowers meaningfully. Energy is steadier, post-meal crashes disappear, and longevity markers improve.
✦ How it works
Get started in three simple steps
Your personalized treatment plan is just minutes away.
≈ 5 minutes
Share your story
A brief, 100% online health assessment from the comfort of your home.
Within 24 hours
A clinician reviews
Board-certified physicians review your answers and build a tailored plan within 24 hours.
Free shipping
Care, delivered
If a prescription is granted, it ships discreetly to your door — free.
FAQ
Questions,
answered.
Everything you need to know before starting your protocol. Still curious? Our care team is one message away.
01What can I expect with Metformin treatment?
Fasting glucose typically begins to improve in the first week or two. Appetite and cravings stabilize by weeks 4–8, and by month three most men see meaningful changes in HbA1c, energy stability and body composition.
02What are the possible side effects of Metformin?
The most common are gastrointestinal — nausea, loose stools or bloating — usually mild, dose-dependent and improved by taking it with food. The extended-release form reduces these further. Rare risks are reviewed by your clinician during intake.
03How is Metformin taken?
One extended-release tablet daily, typically with your evening meal. Your clinician sets the starting dose and titrates slowly to minimize GI adjustment.
04Is this an off-label use?
Metformin is FDA-approved for type 2 diabetes. When prescribed for insulin sensitivity and metabolic health in non-diabetic patients, it is off-label. Risks, benefits and alternatives are reviewed with you by a US-licensed clinician.
Membership
What's included
One price. Everything you need — prescription, physician care and concierge support.
Treatment + ongoing care
Your prescription plus continuous physician support.
Free delivery to your door
Discreet, fast shipping included with every order.
Online doctor consultation
Evaluated by a licensed U.S. physician — no office visit needed.
Message your provider anytime
Ongoing care and adjustments whenever you need them.
100% money-back guarantee
Full refund if you're not approved for treatment.